colon-cancer

Colon cancer is now spreading in developed countries. It is a very common cancer that is more likely to develop from a certain age. Fortunately, it is a tumor that if detected at early stages, the operation is usually quite successful.

Data from some research on reishi and colon cancer (in vitro and in vivo – mice):

Regarding protection, triterpenes contained in reishi (Ganoderma lucidum mushrooms) protect intestinal cells in mice in whom ulcerative colitis was chemically induced (PhIP (2-Amino-1-methyl-6-phenyl-imidazo [4,5-b ] Pyridine). Reishi diminishes DNA damage as well as damage to the P53 gene, which controls cell death (when the gene is inhibited, cells reproduce without dying, which occurs in many cancers).

Another study linked below states that reishi substances cause the destruction of some colon cancer cells (apoptosis).

As shown in the charts of this Japanese study, Antioxidant and Anticancer Effects of Edible and Medicinal Mushrooms, reishi inhibits the development of colon cancer cells by more than 70% thanks to triterpenes contained in reishi (studies in vitro).

On the other hand, let’s mention that the fiber contained in the mushroom (not extracts, which lack it) is able to drag carcinogenic substances along the intestine as well as being very suitable for the health of the intestinal flora.

 

Studies and research:

Ganoderic acid Me induces apoptosis through mitochondria dysfunctions in human colon carcinoma cells

A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas.

A water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia suppresses azoxymethane-induction of colon cancers in male F344 rats.

Ganodermanontriol, a lanostanoid triterpene from Ganoderma lucidum, suppresses growth of colon cancer cells through beta-catenin signaling.

Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK).

Ganoderma lucidum extract inhibits proliferation of SW 480 human colorectal cancer cells.

Immune Responses to Water-Soluble Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.) P. Karst. Polysaccharides in Patients with Advanced Colorectal Cancer

Effects of Ganoderma lucidum on apoptotic and anti-inflammatory function in HT-29 human colonic carcinoma cells.

Prevention of development of N,N’-dimethylhydrazine-induced colon tumors by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male ICR mice.